The big C is certainly one to cure. Up next, possibly HIV.
Saying that, curing the common cold may be a good one too - less lives saved, I admit, but quality of life increases.
The last one to cure, once we've sorted out a whole bunch of other stuff, would be old age. I'm including this as an "ailment" as basically all your organs start to deteriorate. However, curing this is a two edged sword as then there'd be a population explosion unless we all stop procreating :-)